ZIA CP000112 - 00377 (ZIA) | |||
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Title | Linxian nutrition intervention trial follow-up study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Taylor, Philip | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $170,195 | Project Dates | 09/01/1994 - 00/00/0000 |
Fiscal Year | 2014 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Chemoprevention (100.0%) Digestive Diseases (100.0%) Herpes - Other (20.0%) |
Esophagus (50.0%) Liver Cancer (5.0%) Lung (5.0%) Stomach (40.0%) Vascular Disease (20.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Dietary Interventions to Reduce Cancer Risk and Nutritional Science in Cancer Prevention |
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Abstract | |||
Two large, nutrition intervention trials were conducted in Linxian China between 1985-1991. These trials tested the effect of multiple vitamins and minerals in the prevention of esophageal cancer in a population with the highest known rate for this disease in the world. Results from the trials showed that beta carotene + vitamin E + selenium reduced total mortality, total cancer mortality, and gastric cancer incidence and mortality. Multivitamins/minerals also showed a reduction in esophageal cancer pre-malignant lesions. Follow-up of all trial participants has continued since the cessation of supplementation in 1991 and information and biologic specimens on participants have been further augmented by a nutritional survey (n~1000) in 1999 and a blood collection survey (n~16000) in 1999-2000. Post-intervention follow-up data through 2001 show that the observed benefits for total and cancer mortality are reduced but that the benefit for gastric cancer remains. Benefits for total cancer, gastric cancer, and esophageal cancer mortalities in the General Population Trial are most apparent in younger participants and persist for years after cessation of supplementation. Further post-intervention analysis in both trials, including additional sub-group analyses by age, gender, and other factors is in progress." |